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Immunoglobulin levels immunoglobulin g immunoglobulin a and immunoglobulin m during normal pregnancy and after delivery



Immunoglobulin levels immunoglobulin g immunoglobulin a and immunoglobulin m during normal pregnancy and after delivery



Zentralblatt fuer Gynaekologie 106(15): 1084-1091



IgG, IgA and IgM levels in maternal serum of 16 healthy pregnant women were analyzed between the 7th and 37th week (n = 95) and at the second day after delivery. Serum Ig concentrations of 54 healthy nonpregnant young women are the base for delivery-specific normal levels. IgA and IgG rise at the beginning of pregnancy and decrease after the 17th week; IgA levels after 20th week of pregnancy are not different from concentrations of non-pregnant women. IgG levels fall below the prepregnancy norm significantly. This continuous decrease lasts until the second day following delivery, IgM decreases immediately with starting pregnancy; the following decrease is unessential. After delivery, levels rise rapidly. A shortlasting decrease of the concentration of IgG, IgA and IgM with consecutive increase between the 11th and 14th gestational week is a special characteristic sign.

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