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Immunoglobulin levels in bronchoalveolar lavage fluid of children with recurrent obstructive bronchitis



Immunoglobulin levels in bronchoalveolar lavage fluid of children with recurrent obstructive bronchitis



Acta Paediatrica Hungarica 27(3): 205-210



Bronchoalveolar lavage was performed in 22 children with recurrent obstructive bronchitis and the recovered lavage fluid samples were analysed for concentration of IgA, IgG, IgM, IgE and C3. Previously a significant influx of exudate macrophages and persistence of bacteria on the bronchoalveolar surface were detected in these patients and a severe mucosal inflammation was observed bronchoscopically. The relative lavage fluid levels of immunoglobulins to albumin were significantly higher than in serum, indicating a local production of these proteins. The elevated levels of C3 indicated a high activity of the macrophages and the complement system. It is concluded that the mucosal inflammation in patients with recurrent obstructive symptoms cannot be attributed to a deficiency of immunoglobulins either in blood or in bronchial secretions.

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Accession: 005631200

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PMID: 3778669


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