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Immunological response of six inbred mouse strains infected by three different stains of trypanosoma cruzi

Immunological response of six inbred mouse strains infected by three different stains of trypanosoma cruzi

Memorias do Instituto Oswaldo Cruz 80(2): 203-212

We evaluated humoral and cellular immune responses in 6 inbred mouse strains (BALB/c, B-10. C3H, A/J, AKR and DBA) infected with 3 Trypanosoma cruzi strains (Peruvian, 21 SF and Colombian), which are the standards for the 3 strains types of Andrade's classification. Negative delayed-type hypersensitivity reactions to parasite antigens were evidence of suppressed cell-mediated immunity. An early drop of IgG1 and rise of IgM levels were observed in almost all mouse strains infected by any T. cruzi strain. Elevation of IgG2a and/or IgG2b levels was higher in resistant mouse strains. Anti-T. cruzi antibody levels (Indirect immunofluorescence and ELISA) did not correlate with survival. Despite some differences among mouse strains there was a definition of an overall pattern of host response and the maintenance of biological standards which characterize the basic types of T. cruzi strains.

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