+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Immunological response of six inbred mouse strains infected by three different stains of trypanosoma cruzi



Immunological response of six inbred mouse strains infected by three different stains of trypanosoma cruzi



Memorias do Instituto Oswaldo Cruz 80(2): 203-212



We evaluated humoral and cellular immune responses in 6 inbred mouse strains (BALB/c, B-10. C3H, A/J, AKR and DBA) infected with 3 Trypanosoma cruzi strains (Peruvian, 21 SF and Colombian), which are the standards for the 3 strains types of Andrade's classification. Negative delayed-type hypersensitivity reactions to parasite antigens were evidence of suppressed cell-mediated immunity. An early drop of IgG1 and rise of IgM levels were observed in almost all mouse strains infected by any T. cruzi strain. Elevation of IgG2a and/or IgG2b levels was higher in resistant mouse strains. Anti-T. cruzi antibody levels (Indirect immunofluorescence and ELISA) did not correlate with survival. Despite some differences among mouse strains there was a definition of an overall pattern of host response and the maintenance of biological standards which characterize the basic types of T. cruzi strains.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 005635022

Download citation: RISBibTeXText


Related references

Anti heart response and histopathology in resistant inbred mouse strains chronically infected with trypanosoma cruzi. FASEB Journal 5(5): A1365, 1991

Differential cardiac histopathology in inbred mouse strains chronically infected with Trypanosoma cruzi. Journal of Parasitology 78(6): 1059-1066, 1992

In situ characterization of the myocardial inflammatory infiltrate in different mouse inbred strains infected with Trypanosoma cruzi. Memorias do Instituto Oswaldo Cruz 94(Suppl. 2): 171, 1999

Immunological aspects of infection of 6 inbred strains of mice by 3 different strains of Trypanosoma cruzi. Memorias do Instituto Oswaldo Cruz 80(2): 203-211, 1985

Lymphokine release by spleen cells from trypanosoma cruzi infected inbred strains of mice. Molecular & Biochemical Parasitology (Suppl.): 29, 1982

Heterogeneity in the plasma levels of two acute-phase proteins in mice from inbred strains infected with Trypanosoma cruzi. Parasitology Research 80(5): 439-441, 1994

Acquired Immunity In Mice Infected With Strains Of Immunological Types A And B Of Trypanosoma Cruzi. Experimental Parasitology 14: 233-239, 1963

Trypanosoma cruzi: role of the immune response in the natural resistance of inbred strains of mice. Experimental Parasitology 45(2): 160-168, 1978

Trypanosoma cruzi: regulation of mitogenic responses during infection in genetically resistant and susceptible inbred mouse strains. Experimental Parasitology 59(1): 33-43, 1985

Immunological response of Swiss mice to infection with three different strains of Trypanosoma cruzi. Annals of Tropical Medicine and Parasitology 79(4): 397-407, 1985

Trypanosoma cruzi correlation of resistance and susceptibility in infected inbred mice with the in vivo primary antibody response to sheep red blood cells. Experimental Parasitology 52(2): 233-242, 1981

Trypanosoma cruzi immuno suppressed response to different antigens in the infected mouse. Experimental Parasitology 45(2): 190-199, 1978

Genetic quality control of inbred mouse strains 2. determination of some morphological and immunological markers in 23 inbred strains of mice. Zwierzeta Laboratoryjne 20(1-2): 55-66, 1983

Differentiation by micro immuno fluorescence of trypanosoma cruzi and trypanosoma cruzi like strains from trypanosoma conorhini and trypanosoma rangeli using protection from the sponge aaptos papillata. Zeitschrift fuer Parasitenkunde 57(3): 213-220, 1978

Cd hyperfine interactions in DNA bases and DNA of mouse strains infected with Trypanosoma cruzi investigated by perturbed angular correlation spectroscopy and ab initio calculations. Biochemistry 53(21): 3446-3456, 2014