Impulse activity of cortical neurons and general anesthesia

Bogdanov, K.Iu.; Vagina, M.A.

Vestnik Akademii Meditsinskikh Nauk SSSR 1979(9): 7-10


ISSN/ISBN: 0002-3027
PMID: 494736
Accession: 005644068

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A common mechanism in the action of different general anesthetics is the transformation of spontaneous impulse activity of cortical neurons into a packet form. This was demonstrated using joint interval histograms, both for anesthetics leading to an increase in the average rate of spontaneous activity (ketamine) and for those leading to its decrease (althesin, ftorotan, propanidid) in cats. In the packet form of spontaneous activity the cell discontinues participation in the treatment of information coming from the outside. The loss of consciousness in general anesthesia may be due to the transformation of the neuronal activity into the packet form.