Section 6
Chapter 5,646

In vitro and in vivo anti bacterial activity of t 1982 sodium 7 beta 2r 3s 2 4 ethyl 2 3 dioxo 1 piperazinecarboxamido 3 hydroxybutanamido 7 alpha methoxy 3 1 methyl 1h tetrazol 5 ylthiomethyl 3 cephem 4 carboxylate a new semi synthetic cephamycin antibiotic

Tai, M.; Fukuoka, Y.; Yotsuji, A.; Kumano, K.; Takahata, M.; Mikami, H.; Yasuda, T.; Saikawa, I.; Mitsuhashi, S.

Antimicrobial Agents and Chemotherapy 22(5): 728-734


ISSN/ISBN: 0066-4804
Accession: 005645911

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The activities of T-1982 (sodium 7.beta.-[(2R,3S)-2-(4-ethyl-2,3-dioxo-1-piperazine-carboxamido)-3-hydroxybutanamidol]-7.alpha.-methoxy-3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylate) against various gram-positive and gram-negative bacteria were compared with those of cefmetazole, cefoxitin, cefazolin, and cefoperazone. T-1982 was active against both gram-positive and gram-negative bacteria, including genera resistant to the other cephalosporins. T-1982 exhibited greater activity than did cefmetazole, cefoxitin, cefazolin or cefoperazone against Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Serratia marcescens and was also highly active against Bacteroides fragilis. T-1982 was as stable to various .beta.-lactamases as were cefmetazole and cefoxitin. The therapeutic activities of T-1982 in mice experimentally infected with various gram-negative bacteria were superior to those of cefmetazole, cefoxitin, cefazolin and cefoperazone.

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