In vitro metabolism of sulindac and sulindac sulfide: enzymatic formation of sulfoxide and sulfone

Kitamura, S.; Tatsumi, K.

Japanese Journal of Pharmacology 32(5): 833-838

1982


ISSN/ISBN: 0021-5198
PMID: 7176218
DOI: 10.1254/jjp.32.833
Accession: 005649914

Download citation:  
Text
  |  
BibTeX
  |  
RIS

Article/Abstract emailed within 0-6 h
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Abstract
Liver 9000 .times. g supernatants from guinea pigs, rabbits and dogs could catalyze the oxidation of both sulindac sulfide and sulindac , N-ethyl-maleimide and potassium cyanide. CO inhibited only the oxidation of sulindac. The microsomal sulindac oxidase activity was enhanced 4-fold by 3-methylcholanthrene treatment.