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In vitro spleen cell responsiveness to various analogs of n acetylmuramyl l alanyl d iso glutamine a synthetic immuno adjuvant in n acetylmuramyl l alanyl d iso glutamine high responder mice



In vitro spleen cell responsiveness to various analogs of n acetylmuramyl l alanyl d iso glutamine a synthetic immuno adjuvant in n acetylmuramyl l alanyl d iso glutamine high responder mice



Cellular Immunology 35(1): 173-179



N-Acetylmuramyl-L-alanyl-D-isoglutamine (MDP), a synthetic immunoadjuvant, was incubated with spleen cells of DBA/2 or Balb/c mice and optimal responses were obtained after 4 or 5 days of culture in a serum-free medium supplemented with 2-mercaptoethanol. In contrast, lymphocytes of (C57Bl/6 .times. AKR)F1 hybrids responded weakly under the same conditions. In the case of DBA/2 and Balb/c strains, spleen cells of Swiss mice and of inbred AKR and CBA mice could be stimulated in vitro whereas C57Bl/6 and LPS[lipopolysaccharide from Salmonella enteritidis]-refractory C3H/He mice did not respond. Fourteen synthetic MDP analogs (eight known to be adjuvant active and six devoid of activity) were tested in DBA/2 high-responder mice. A good correlation was observed between in vitro stimulation and the presence or absence of adjuvant activity in vivo of these compounds. [A water-soluble peptidoglycan arabino-galactan complex having adjuvant activity was extracted from Mycobacterium smegmatis].

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Accession: 005651400

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