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In vitro studies of 5 10 methylene tetra hydro folate reductase ec 1.1.1.171 inhibition by folate derivatives folate antagonists and mono amine derivatives



In vitro studies of 5 10 methylene tetra hydro folate reductase ec 1.1.1.171 inhibition by folate derivatives folate antagonists and mono amine derivatives



Journal of Neurochemistry 38(3): 638-642



Folate monoglutamates and folate antagonists have an inhibitory action on the activity of 5,10-methylenetetrahydrolate reductase in rat brain. The type of inhibition was studied for dihydrofolic acid using the Lineweaver-Burk transformation. Some of the monoamine alkaloids, the in vitro products of 5,10-methylenetetrahydrofolate reductase, have either a stimulatory or inhibitory effect on the enzyme activity.

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Accession: 005651567

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