In vivo enamel fluoride uptake from and caries inhibition by topical fluoride agents
Gibbs, M.; Retief, D.H.; Bradley, E.L.; Taylor, R.E.; Walker, A.R.
Journal of Dental Research 60(4): 770-775
ISSN/ISBN: 0022-0345 PMID: 6937513 DOI: 10.1177/00220345810600040101
Acidulated phosphate fluoride (APF), Duraphat or Fluor Protector, was applied to the molar teeth of rats fed a cariogenic diet. The first maxillary molar teeth were subjected to a microbiopsy procedure for fluoride analysis and the mandibular molars scored for caries. All three topical fluoride agents produced a significant increase in the fluoride content of the outermost 5.0 micron of enamel. Only APF produced a significant reduction in caries incidence at all sites.