EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Inability of tumor cells to elicit the respiratory burst in cyto toxic activated macrophages



Inability of tumor cells to elicit the respiratory burst in cyto toxic activated macrophages



Immunology 45(3): 577-586



Activated macrophages from Corynebacterium parvum[Propionibacterium-acnes]-treated mice are cytotoxic to non-antibody-coated tumor cells and have an augmented respiratory burst potential when compared to resident macrophages. The possible involvement of the respiratory burst as an effector mechanism in this type of tumor killing was studied. Scavengers of toxic metabolites of oxygen such as catalase, superoxide dismutase, 2,3-dihydroxybenzoate, ethanol, and cytochrome c did not inhibit macrophage cytotoxicity in this system. To investigate whether or not neoplastic cells stimulate the macrophage respiratory burst, activated macrophages were exposed to viable tumor cells and the resultant macrophage superoxide anion production, chemiluminescence and hexose monophosphate shunt activity were monitored. None of the indicators of macrophage respiratory burst was stimulated by the tumor cells towards which the macrophages were cytotoxic. The data suggest that the respiratory burst is not utilized as an effector mechanism in the non-antibody-mediated macrophage tumor cytotoxicity reaction.

(PDF 0-2 workdays service: $29.90)

Accession: 005656342

Download citation: RISBibTeXText

PMID: 6277777



Related references

Tumor cells elicit the respiratory burst in cytotoxic activated bone marrow derived macrophages bmdm. Pathobiology 60(SUPPL 1): 18, 1992

Cyto toxic action of macrophages activated by bcg on tumor target cells in vitro. Bulletin of Experimental Biology & Medicine 87(1): 42-45, 1979

Inability of sub cellular fractions to elicit primary anti h 2 cyto toxic t lymphocytes. Cellular Immunology 58(2): 277-285, 1981

Activated macrophages as cyto toxic effector cells part 1 inhibition of specific and nonspecific tumor resistance by trypan blue. Transplantation (Baltimore) 19(1): 77-81, 1975

Susceptibility of malignant and normal target cells to the cyto toxic action of bone marrow macrophages activated in vitro with the macrophage cyto toxicity factor. Cellular Immunology 41(2): 231-239, 1978

Lymphocyte mediated cyto toxicity against tumor cells part 3 differentiation of concanavalin a activated cyto toxic effector cells. European Journal of Immunology 6(5): 317-320, 1976

Lymphocyte mediated cyto toxicity against tumor cells part 1 concanavalin a activated cyto toxic effector cells exhibit immunological specificity. Cellular Immunology 17(2): 392-404, 1975

Lymphocyte mediated cyto toxicity against tumor cells part 2 characteristics and tissue distribution of concanavalin a activated cyto toxic effector cells. European Journal of Immunology 6(5): 309-316, 1976

In vitro study of the cyto toxic effect of bcg activated macrophages on tumor target cell. Byulleten' Eksperimental'noi Biologii i Meditsiny 87(1): 36-39, 1979

Lymphocyte mediated cyto toxicity against tumor cells characterization of the concanavalin a activated cyto toxic effector cell. Scandinavian Journal of Immunology 4(7): 767-768, 1975

Susceptibility of various target cells to the cyto toxic action of activated macrophages. Zeitschrift fuer Immunitaetsforschung 153(4): 331-332, 1977

Lymphocyte mediated cyto toxicity against allogeneic tumor cells 4. fine specificity mapping and characterization of concanavalin a activated cyto toxic effector lymphocytes. Immunology 44(4): 685-694, 1981

Cholera toxic differentially regulates nitric oxide synthesis, tumor necrosis factor-alpha production and respiratory burst in murine macrophages. FEMS Immunology & Medical Microbiology 22(3): 193-198, 1998

Activated macrophages as cyto toxic effector cells part 2 requirement for local persistence of inducing antigen. Transplantation (Baltimore) 19(1): 81-87, 1975