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Increase in intra cisternal a type particles in friend cells during inhibition of friend virus spleen focus forming virus release by interferon or azido thymidine



Increase in intra cisternal a type particles in friend cells during inhibition of friend virus spleen focus forming virus release by interferon or azido thymidine



Experimental Cell Research 116(1): 21-30



Interferon or azidothymidine inhibition of Friend virus (FV-SFFV [spleen focus-forming virus]) release in [murine] Friend erythroleukemic cells results in a 10- to 20-fold increase in intracisternal A-type particle number within 3-4 days of treatment. Inhibition of Friend or Moloney helper virus by interferon in fibroblast producer cells does not result in a similar increase in intracisternal A-type particles. Friend cells with marginal FV production but with high levels of A-type particles do not change their A-type particle levels upon exposure to interferon. A-type particle expression in Friend cells may be linked to the presence of the transforming SFFV. No marked increase of viral RNA levels during inhibition of virus release is observed in Friend cells.

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Accession: 005661456

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Related references

Increase in intracisternal A-type particles in Friend cells during inhibition of Friend virus (SFFV) release by interferon or azidothymidine. Experimental Cell Research 116(1): 21-29, 1978

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