Increase of right ventricular fractional myo cardial uptake of thallium 201 in patients with hypertrophic cardio myopathy

Miyanaga, H.; Adachi, H.; Sugihara, H.; Torii, Y.; Watanabe, T.; Katume, H.; Ijichi, H.

Kaku Igaku 20(3): 329-333


Accession: 005662147

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Right and left ventricular uptake of 201Tl was measured for the detection of hypertrophic involvement of right ventricle (RV) in the patients with hypertrophic cardiomyopathy (HCM). Thirty subjects fractional myocardial uptake in HCM (6.41 .+-. 1.77%) (mean .+-. 1 SD) was significantly greater than in HHD (4.90 .+-. 0.84%, P < 0.05) and in normal subjects (3.84 .+-. 0.54%, P < 0.01). The RV fractional myocardial uptake in HCM (2.28 .+-. 0.82%) was also greater than in HHD (1.56 .+-. 0.35%, P < 0.05) and in normal subjects (1.39 .+-. 0.37%, P < 0.01), but fractional myocardial uptake ratio of RV to LV showed no significant difference in 3 groups. Because the fractional myocardial uptake of 201Tl was assumably proportional to the fractional myocardial blood flow to cardiac output (MBF/CO) according to the indicator fractional principle, and increase of myocardial blood flow was thought to be mainly due to increase of myocardial mass. In HCM, there were not only increase of myocardial blood flow but also myocardial muscle mass in both ventricles. Apparently, the measurement of RV fractional myocardial uptake was valuable for the evaluation of RV involvement in HCM.