Increased peritoneal permeability in patients with peritonitis undergoing continuous ambulatory peritoneal dialysis
McIntosh, M.E.; Smith, W.G.; Junor, B.J.; Forrest, G.; Brodie, M.J.
European Journal of Clinical Pharmacology 28(2): 187-191
The distribution of cefuroxime (250 mg) was studied in patients with renal failure undergoing continuous ambulatory peritoneal dialysis (CAPD). Uninfected patients (10) received the drug i.v. and i.p. while 9 patients with peritonitis were randomly allocated to i.v. or i.p. administration. Samples were taken over the first 6 h dialysis period. In the infected patients, more drug (P < 0.01) crossed into the peritoneal cavity following i.v. injection and reached the systemic circulation following i.p. administration than in the uninfected group. This increased permeability of the peritoneal membrance during infection may result in unexpected systemic toxicity in patients treated with i.p. antibiotics.