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Individual ev loci determine characteristic patterns of endogenous retroviral envelope antigen expression during lymphocyte maturation



Individual ev loci determine characteristic patterns of endogenous retroviral envelope antigen expression during lymphocyte maturation



Virology 133(1): 128-136



A comparative study of the expression of retroviral envelope antigen by T and B lymphocytes at different maturational stages was made with chickens typed for genomic ev loci. All lymphocyte subclasses from chf(.sbd.) chickens were negative for expression of retroviral envelope antigen. Lymphocyte lineage cells from all the chf(+) lines examined were positive for expression, with the levels of envelope antigen in the lymphoblasts exceeding the levels in the immature and resting cells. This pattern of lymphocyte expression was found in lines of chickens in which the expression of chf in fibroblasts was encoded by the ev 3, ev 6 or ev 9 loci. Plasma cells from those chf(+) lines possessing ev6 expressed higher levels of envelope antigen than the lymphoblasts, an effect not observed with the chf(+) lines lacking ev 6.

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Accession: 005668728

Download citation: RISBibTeXText

PMID: 6322424

DOI: 10.1016/0042-6822(84)90431-8


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