+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Induction of differentiation in human promyelocytic leukemia cells by tumor promoters



Induction of differentiation in human promyelocytic leukemia cells by tumor promoters



Science 204(4395): 868-870



Phorbol diester tumor promoters and the promoter mezerein convert human promyelocytic leukemia cells in culture into adherent, nonproliferating cells with many of the characteristics of macrophages. Other types of promoters such as anthralin, phenobarbital, and saccharin do not have this effect. Various compounds that can inhibit some of the biological and biochemical effects of tumor promoters do not interfere with the induction of cell adherence and differentiation by the effective promoters.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 005672171

Download citation: RISBibTeXText

PMID: 286421

DOI: 10.1126/science.286421


Related references

Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents. Proceedings of the National Academy of Sciences of the United States of America 76(3): 1293-1297, 1979

Induction of differentiation of human promyelocytic leukemia cells (HL-60) by arginase. Cancer Letters 10(4): 287-292, 1980

Induction of differentiation of hl 60 human promyelocytic leukemia cells by 3 deazapurines. Scott, W N And F L Strand (Ed ) Annals Of The New York Academy Of Sciences, Vol 435 First Colloquium in Biological Sciences; Meeting, New York, N Y , Usa, Nov 11, 1983 Xvii+621p New York Academy Of Sciences: New York, N Y , Usa Illus 126-128, 1984, 1985

Induction of differentiation of human promyelocytic leukemia cells (HL-60) by nucleosides and methotrexate. Journal of the National Cancer Institute 67(5): 1025-1030, 1981

Differentiation induction of human promyelocytic leukemia cells with colletochlorin b and its analogues. Chemical & Pharmaceutical Bulletin 36(1): 452-455, 1988

Induction of differentiation in human promyelocytic leukemia HL-60 cells by alpha-anordrin. Zhongguo Zhongliu Linchuang 26(10): 739-742, 1999

Induction of apoptosis and differentiation in human promyelocytic leukemia cells by 2- pyrazine. Proceedings of the American Association for Cancer Research Annual Meeting 40: 395, 1999

Induction of differentiation of human promyelocytic leukemia (HL-60) cells by new retinoid R-81001. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae 11(2): 102-106, 1989

Stimulation by interferon of induction of differentiation of human promyelocytic leukemia cells. Biochemical & Biophysical Research Communications 104(1): 30-37, 1982

Differentiation induction of human promyelocytic leukemia cells by 10-hydroxycamptothecin, a DNA topoisomerase I inhibitor. Differentiation; Research in Biological Diversity 46(2): 135-141, 1991

Induction of morphological and functional differentiation of human promyelocytic leukemia cells (HL-60) by Tubeimoside 1. Planta Medica 62(2): 119-121, 1996

Induction of differentiation in human pro myelocytic leukemia cells by tumors promoters. Journal of Cancer Research & Clinical Oncology 103(1): 17-30, 1982

Differentiation induction of human promyelocytic leukemia cells by acyclic retinoid (polyprenoic acid). International Journal of Hematology 59(1): 9-15, 1993