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Induction of rat endometrial estradiol 17 beta dehydrogenase activity by estradiol and progesterone



Induction of rat endometrial estradiol 17 beta dehydrogenase activity by estradiol and progesterone



Biology of Reproduction 22(2): 159-163



Estradiol-17.beta. dehydrogenase (E2DH) activity in rat endometrium is undetectable in the castrated rat but can be induced by E2 [estradiol] stimulation. When E2 was given alone for 3 days, the E2DH activity induced was linearly related to the log of the dose administered (r [correlation coefficient] = 0.90, P < 0.005). Administration of progesterone (P) with the 3rd E2 injection decreased the enzyme activity, but a linear relationship was still observed with the log of the dose of E2 administered (r = 0.77, P < 0.005). P alone was not able to induce E2DH activity. When P was administered for 3 day and E2 was added with the last P injection, the effect of this single dose of E2 was magnified. A time lag was observed between E2 administration and the induction of E2DH activity when the dose of E2 was 0.1 .mu.g. When the single dose of E2 was increased to 2 .mu.g, the time lag was shortened. After induction in these conditions, P alone was able to maintain E2DH activity. Changes in the enzyme activity are under the control of both ovarian hormone E2 and P. The development of endometrial E2DH activity during the first 10 days of pregnancy is explained. The variations observed during the estrous cycle, an observation which suggests the intervention of a 3rd factor not yet elucidated remain unclear.

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Accession: 005674627

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PMID: 6929711


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