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Industrial styrene poisoning 12. electron microscopic observations on the mucosal membrane of respiratory tracts of rats exposed to styrene



Industrial styrene poisoning 12. electron microscopic observations on the mucosal membrane of respiratory tracts of rats exposed to styrene



Japanese Journal of Industrial Health 23(5): 513-529



Styrene causes stimulation of the mucosal membrane and atrophy of the CNS in man. There are several clinical reports and animal experiments concerning the stimulation of the mucosal membrane and styrene is presumed to stimulate the mucosal membrane of the nose. Rats were used to study influences of styrene on the mucosal membrane of the upper and lower respiratory tracts including the mucosal membrane of the nose. Changes confirmed by EM were: increased amount of mucus adhering to cilia, occasional formation of compound cilia, appearance of substances having a higher EM density within the cytoplasm of various epithelial clls, degeneration of secretory granules of goblet cells (changes in EM density and appearance of cores with a higher EM density), nuclear pyknosis, vacuolization of epithelial cells and separation and falling-off of the epithelial cell layer.

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