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Influence of 0.5 parts per million nitrogen di oxide exposure of mice on macrophage congregation in the lungs



Influence of 0.5 parts per million nitrogen di oxide exposure of mice on macrophage congregation in the lungs



In Vitro 14(5): 458-464



The lungs of 12 mice, half of which were exposed to continuous 0.5 ppm NO2 for 3 wk, were explained in culture, and the instances of macrophage congregation were quantitated according to numbers of target cells involved, categories of congregation from 3-11 or more, numbers of macrophages participating in each category for the total cultures, and the influence of delaying explantation for 24 and 96 h. A total of 9042 macrophages and 2140 epithelial and spindle target cells were counted in the outgrowths from 306 explants. The incidence of macrophage congregation (or numbers of target cells) was greater for the cultures from the NO2-exposed animals, both with respect to total incidences between groups (P .fwdarw. 0), and the 0 h (P < 0.001) and 24 h (P < 0.01) culture subgroups. The values for T3-T6 macrophage congregation were individually and consistently greater for the exposed animal group. Postmortem interval stress at 96 h appeared to result in large colonies, but they were reduced greatly in number. Also the incidence of macrophage congregation fell by 28% as compared to 0 h and 24 h subgroups.

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