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Influence of alpha adrenoceptors and beta adrenoceptors on the release of noradrenaline from field stimulated atria and cerebral cortex slices


, : Influence of alpha adrenoceptors and beta adrenoceptors on the release of noradrenaline from field stimulated atria and cerebral cortex slices. Journal of Pharmacy and Pharmacology 26(8): 644-646

Desirpramine [10-7 M] increased the stimulation-induced overflow of mouse atria by about 50%. Phenoxybenzamine (10-6 M) doubled the stimulation-induced overflow. As phenoxybenzamine is a much less potent inhibitor of the membrane pump than desipramine, the effect of phenoxybenzamine is probably, to a large extent, due to its .alpha.-adrenoceptor blocking activity. The .alpha.-adrenoceptor stimulating drugs, clonidine and DCBAG (2,6-dichlorobenzylidene aminoguanidine), decreased the stimulation-induced overlow to about 70% of the control. In rat cerebral cortex slices, phentolamine significantly increased and DCBAG significantly decreased the stimulation-induced overflow. Propranolol 10-6 M slightly enhanced the stimulation-induced overflow in the mouse atria, probably due to its uptake inhibiting property. Propranolol 10-5 M considerably reduced the stimulation-induced overflow. This effect is most likely due to the local anesthetic property of this drug. Isoprenaline did not significantly alter the stimulation-induced overflow from the mouse atria. In cerebral cortex slices propranolol was without effect, while isoprenaline 10-5 M caused a 20% increase of the stimulation-induced overflow, possibly due to slight inhibition of the membrane pump.

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