+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Influence of beta adrenoceptor blockade by metoprolol and propranolol on plasma concentrations and effects of noradrenaline and adrenaline during intra venous infusion



Influence of beta adrenoceptor blockade by metoprolol and propranolol on plasma concentrations and effects of noradrenaline and adrenaline during intra venous infusion



Acta Physiologica Scandinavica Suppl. (515): 45-54



To study the concentration-dependence of responses to circulating noradrenaline (NA) [norepinephrine] and adrenaline (ADR) [epinephrine], 6 healthy volunteers received graded i.v. infusions of NA and ADR in a single-blind study. Venous plasma NA was increased step-wise from 1.44 .+-. 0.22 to 12.24 .+-. 2.47 nM and ADR from 0.28 .+-. 0.10 to 4.05 .+-. 0.67 nM. NA increased systolic and diastolic blood pressures (SBP and DBP) and reduced heart rate (HR) at about 6 nM in venous plasma. ADR decreased DBP concentration-dependently, but increased SBP and HR only at 4 nM. ADR increased plasma cAMP significantly at 0.7 nM. Increases in subjective ratings of discomfort were obtained at 1.9-4 nM ADR and 12 nM NA in plasma. The subjective effects of ADR were counteracted by propranolol but not by the .beta.1-selective antagonist metoprolol, whereas both blockers tended to reduce responses to NA. Metoprolol enhanced NA and ADR concentrations during infusions by 65-75% at the highest infusion rates. Propranolol enhanced ADR levels considerably more than NA levels (by 189 and 75%, respectively, at the highest infusion rates). The 2 .beta.-blockers reduced resting HR and SBP but not DBP or cAMP. Responses to NA were similar during .beta.-blockade. Metoprolol did not influence the plasma cAMP response to ADR but attenuated the DBP reduction. HR remained unchanged. Propranolol antagonized the plasma cAMP response to ADR markedly and caused ADR to increase DBP and decrease HR. Both NA and ADR may act as circulating hormones, and differences in the response pattern may be related to the .beta.-agonist properties of ADR. Caution should be exerted when evaluating sympatho-adrenal activity by plasma catecholamine measurements since .beta.-blockade alters catecholamine kinetics in plasma and since this effect varies with different .beta.-blockers.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 005681009

Download citation: RISBibTeXText


Related references

Influence of beta-adrenoceptor blockade by metoprolol and propranolol on plasma concentrations and effects of noradrenaline and adrenaline during i.v. infusion. Acta Physiologica Scandinavica. Supplementum 515: 45-53, 1983

Beta-adrenoceptor blockade and psychic stress in man. A comparison of the acute effects of labetalol, metoprolol, pindolol and propranolol on plasma levels of adrenaline and noradrenaline. British Journal of Clinical Pharmacology 13(Suppl 2): 391s-395s, 1982

Effects of acute beta adrenoceptor blockade intra venous metoprolol on plasma norepinephrine concentration and hemodynamics in post myo cardial infarction patients. Zeitschrift fuer Kardiologie 68(7): 441-448, 1979

Plasma potassium and phosphate concentrations--influence by adrenaline infusion, beta-blockade and physical exercise. Acta Medica Scandinavica 221(1): 83-93, 1987

Enhanced exercise noradrenaline concentrations during propranolol treatment: a limiting factor in cardiac beta-adrenoceptor blockade. Canadian Journal of Cardiology 4(6): 262-269, 1988

Pharmacologic antagonism of beta adrenergic blockade in dogs 2. hemodynamic effects of simultaneous intra venous infusion of isoproterenol and dopamine during chronic propranolol administration. Journal of Thoracic and Cardiovascular Surgery 79(1): 103-108, 1980

Effects of adrenoceptor blockade on plasma catecholamine levels during adrenaline infusion. British Journal of Pharmacology 59(1): 3-10, 1977

Beta adrenoceptor blockade by atenolol metoprolol and propranolol in the anesthetized cat. European Journal of Pharmacology 55(3): 263-268, 1979

Beta-Adrenoceptor studies. 4. Influence of albumin on in vitro beta-adrenoceptor blocking and antiarrhythmic properties of propranolol, pindolol, practolol and metoprolol. Naunyn-Schmiedeberg's Archives of Pharmacology 298(1): 29-36, 1977

Plasma renin activity, active and inactive renin concentrations, and their responses to beta 1-adrenoceptor blockade with metoprolol in hyperthyroidism. Hormone and Metabolic Research 18(9): 630-634, 1986

Relationship between arterial and peripheral venous catecholamine plasma catecholamine concentrations during infusion of noradrenaline and adrenaline in healthy volunteers. European Journal of Clinical Pharmacology 43(3): 245-249, 1992

Influence of beta-adrenoceptor antagonists on the pharmacokinetics of rizatriptan, a 5-HT1B/1D agonist: differential effects of propranolol, nadolol and metoprolol. British Journal of Clinical Pharmacology 52(1): 69-76, 2001

Metabolic responses of the whole body, portal-drained viscera and hindquarter to adrenaline infusion: Effects of nonselective and selective beta-adrenoceptor blockade. Canadian Journal of Animal Science 77(2): 307-316, 1997

Plasma concentrations and beta-blocking effects in normal volunteers after intravenous doses of metoprolol and propranolol. Journal of Cardiovascular Pharmacology 2(6): 715-723, 1980

Electro physiologic effects of d propranolol and dl propranolol matched for beta blockade evidence in vivo for effects not mediated by the beta adrenoceptor. Clinical Research 30(2): 181A, 1982