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Influence of continuous gonadotropin releasing hormone agonist treatment on luteinizing hormone and testosterone secretion the response to gonadotropin releasing hormone and the testicular response to human chorionic gonadotropin in male rhesus monkeys



Influence of continuous gonadotropin releasing hormone agonist treatment on luteinizing hormone and testosterone secretion the response to gonadotropin releasing hormone and the testicular response to human chorionic gonadotropin in male rhesus monkeys



Journal of Clinical Endocrinology & Metabolism 58(2): 262-267



Five adult male rhesus monkeys were continuously infused for 56 days with 25 .mu.g/day of GnRH [gonadotropin-releasing hormone] agonist (Wy-40972 [[6-D-Trp,7-N-MeLeu,1-des-Gly,9-O-Pro]LHRH ethylamide]; Ag) using an implanted osmotic pump. Bioassayable serum levels of LH [luteinizing hormone] were elevated 8-fold on the 2nd day of Ag treatment and then declined precipitously to below pretreatment levels by day 15. Serum levels of testosterone (T) changed similarly during Ag treatment, except that the fall in serum LH levels preceded the decline in serum levels of T by at least 2 days. Ag administration also eliminated the diurnal variation in serum LH and T. GnRH administration (50 .mu.g) induced a 13- to 20-fold rise in serum LH and a 3- to 7-fold increase in serum T in control monkeys. After 4 wk of Ag administration, none of the animals responded to GnRH. Both control and experimental monkeys had a rise in serum T in response to hCG [human chorionic gonadotropin] after 7 weeks of Ag treatment. Basal levels of LH and T returned to normal by 12 days posttreatment, and the serum LH and T responses to GnRH were normal 19 days posttreatment. Continuous administration of Ag is an effective method of inducing antifertility effects in male rhesus monkeys; pituitary desensitization is a major factor involved in Ag-induced gonadal dysfunction in this species; and the method of administration may be the critical factor in determining the effectiveness of GnRH agonists.

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Accession: 005682431

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Influence of continuous gonadotropin-releasing hormone (GnRH) agonist treatment on luteinizing hormone and testosterone secretion, the response to GnRH, and the testicular response to human chorionic gonadotropin in male rhesus monkeys. Journal of Clinical Endocrinology and Metabolism 58(2): 262-267, 1984

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