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Influence of manganese on the distribution of essential trace elements 1. regional distribution of manganese sodium potassium magnesium zinc iron and copper in rat brain after chronic manganese exposure

Influence of manganese on the distribution of essential trace elements 1. regional distribution of manganese sodium potassium magnesium zinc iron and copper in rat brain after chronic manganese exposure

Toxicology and Applied Pharmacology 61(2): 227-233

Two groups of 6 male rats were treated i.p. for 30 days with 3.0 mg/kg Mn or 0.9% NaCl. Brain regions (olfactory bulbs, frontal cortex, rest of cortex, corpus callosum, hippocampus, corpus striatum, thalamus, hypothalamus, colliculi, amygdala, mid-brain, pons-medulla and cerebellum) were analyzed by atomic absorption spectrophotometry for the following elements: Mn, Na, K, Mg, Zn, Fe and Cu. Mn accumulated most rapidly in striatum, thalamus and midbrain. Mn content increased by 135 nmol/g dry tissue in striatum, 77 nmol/g in thalamus and 67 nmol/g in midbrain compared to an average brain increase of .apprx. 49 nmol/g. Mn exposure caused Cu concentrations to increase in several regions; levels of K and Zn decreased in certain areas. Significant changes in Na and Mg levels were also observed. There was no significant change in the Fe content of any brain region examined, but a significant positive correlation between Mn distribution and Fe distribution was noted in controls. There was a similar positive correlation between Mn and Cu but not between Mn and any other elements. A significant negative correlation was observed between the distribution patterns of Mn and K.

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