+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Influence of manganese on the distribution of essential trace elements 1. regional distribution of manganese sodium potassium magnesium zinc iron and copper in rat brain after chronic manganese exposure



Influence of manganese on the distribution of essential trace elements 1. regional distribution of manganese sodium potassium magnesium zinc iron and copper in rat brain after chronic manganese exposure



Toxicology and Applied Pharmacology 61(2): 227-233



Two groups of 6 male rats were treated i.p. for 30 days with 3.0 mg/kg Mn or 0.9% NaCl. Brain regions (olfactory bulbs, frontal cortex, rest of cortex, corpus callosum, hippocampus, corpus striatum, thalamus, hypothalamus, colliculi, amygdala, mid-brain, pons-medulla and cerebellum) were analyzed by atomic absorption spectrophotometry for the following elements: Mn, Na, K, Mg, Zn, Fe and Cu. Mn accumulated most rapidly in striatum, thalamus and midbrain. Mn content increased by 135 nmol/g dry tissue in striatum, 77 nmol/g in thalamus and 67 nmol/g in midbrain compared to an average brain increase of .apprx. 49 nmol/g. Mn exposure caused Cu concentrations to increase in several regions; levels of K and Zn decreased in certain areas. Significant changes in Na and Mg levels were also observed. There was no significant change in the Fe content of any brain region examined, but a significant positive correlation between Mn distribution and Fe distribution was noted in controls. There was a similar positive correlation between Mn and Cu but not between Mn and any other elements. A significant negative correlation was observed between the distribution patterns of Mn and K.

(PDF emailed within 1 workday: $29.90)

Accession: 005687666

Download citation: RISBibTeXText


Related references

The influence of manganese on the distribution of essential trace elements. II. The tissue distribution of manganese, magnesium, zinc, iron, and copper in rats after chronic manganese exposure. Journal of Toxicology and Environmental Health 12(2-3): 361-370, 1983

Severe zinc deficiency effects on the distribution of 9 elements potassium phosphorus sodium magnesium calcium iron zinc copper and manganese in regions of the rat brain. Journal of Nutrition 113(10): 1895-1905, 1983

Influence of adrenalectomy and mineralocorticoids and glucocorticoids on the tissue distribution of 10 essential cations potassium rubidium sodium calcium strontium manganese magnesium copper zinc and iron in the rat. Journal de Pharmacologie 16(1): 92, 1985

Retention of major elements (calcium, phosphorus, magnesium, sodium, potassium) and trace elements (iron, copper, manganese, zinc) in broilers by adding coccidiostats. 1972

Mineral and trace element content of cattle hair as indicator of calcium, magnesium, phosphorus, potassium, sodium, iron, zinc, manganese, copper, molybdenum, and cobalt nutrition. VI. The utilization and incorporation of orally administered Manganese-52 in hair, blood and milk of cattle. Arch Tierernahr 17(1/2): 81-86, 1967

Aluminum and manganese tolerance on wheat (Triticum aestivum L.) cultivars. IV. Manganese tolerance as related to P, Ca, Mg, Fe, Mn, Zn, Cu Phosphorus, calcium, magnesium, iron, manganese, zinc, copper and Ca, Fe, and Mn Calcium, iron, manganese respectively in aerial parts and roots.10. 1980

Effect of manganese on essential trace element metabolism: Tissue concentrations and excretion of manganese, iron, copper, cobalt and zinc. Trace Elements in Medicine 10(3): 141-147, 1993

Competition between trace elements effect of manganese on iron and cadmium and magnesium on zinc in tissue distribution and binding to dna. Krippner, Monica (Editor) Trace Mineral Studies With Isotopes in Domestic Animals 151p Illus International Atomic Energy Agency: Vienna, Austria (Dist in The U S By Unipub, Inc : New York, N Y ) 69-75, 1969

Simultaneous determination of the elements copper, zinc, iron and manganese as well as sodium, potassium, calcium and magnesium by flame atomic absorption spectrometry (F-AAS). Nahrung 40(6): 313-318, 1996

Determination of nitrogen phosphorus potassium calcium magnesium sodium iron manganese copper and zinc content in 1 sample of plant material determination of phosphorus iron magnesium and manganese content in ash solutions. Izvestiya Akademii Nauk Azerbaidzhanskoi SSR Seriya Biologicheskikh Nauk (1): 15-22, 1986

Determination of calcium, copper, iron, magnesium, manganese, potassium, sodium, zinc, and chloride concentrations in several brain areas. Analytical Biochemistry 21(2): 169-177, 1967

Regional distribution of manganese, iron, copper, and zinc in the rat brain during development. Analytical and Bioanalytical Chemistry 380(2): 240-246, 2004

Soil tests for copper iron manganese and zinc in histosols 1. the influence of soil properties iron manganese and zinc on the level and distribution of copper. Soil Science 142(3): 153-163, 1986

Distribution of copper, manganese, and iron(II) between phases in aqueous systems containing sodium, potassium, and magnesium chlorides. Geochemistry International 23(8): 107-112, 1986

Distribution of autochthon trace elements iron, zinc, copper and manganese and calcium in germinating Pisum sativum L. Berichte 82 (4) 339-349, 1973