Influence of proquazone biarison on the levels of complement c 3 and complement c 4 in synovial fluid and on immuno globulin m in serum in patients with active rheumatoid arthritis a preliminary report
Scandinavian Journal of Rheumatology Suppl (21): 40-42
Patients (4) with erosive rheumatoid arthritis and 1 with psoriasis arthropathy were treated with 600-900 mg/day proquazone for 4-7 wk. All patients had acute knee effusions. The complement components C3 and C4, and Ig[immunoglobulin]G, IgA, IgM and total protein, were measured in both the synovial fluid and serum before and after treatment. In the 4 patients with rheumatoid arthritis, a marked increase in C3 and/or C4 levels in the synovial fluid was found, correlating in 3 cases with a good clinical response. No corresponding changes in complement levels were recorded in the serum. The patient with psoriasis arthropathy did not show any reaction. These preliminary results suggest that proquazone may influence the immunological processes in rheumatoid arthritis.