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Influence of ramipril on release of norepinephrine during sympathetic nerve stimulation in isolated rabbit hearts



Influence of ramipril on release of norepinephrine during sympathetic nerve stimulation in isolated rabbit hearts



Zhongguo Yao Li Xue Bao 9(4): 320-322



The present study was performed to determine norepinephrine (NE) release during sympathetic nerve stimulation (SNS) and the inhibitory action of ramipril on the release of NE induced by the stimulus in isolated perfused rabbits hearts. SNS resulted in increases of NE ranged from 2.8 .+-. 0.9 ng/ml to 10.2 .+-. 2.7 ng/ml. The addition of ramipril 10 .mu.g/min to the perfusate for 30 min significantly reduced NE release (P < 0.05-0.01). The results suggest that ramipril as an inhibitor of angiotensin converting enzyme (ACEI) may be involved in the angiotensin II-mediated facilitation of adrenergic neurotransmission.

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Accession: 005690737

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PMID: 2973724



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