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Inhibition by bran of the colonic co carcinogenicity of bile salts in rats given di methyl hydrazine



Inhibition by bran of the colonic co carcinogenicity of bile salts in rats given di methyl hydrazine



Experimental & Molecular Pathology 33(2): 133-143



The effects of incorporating bile salts alone or bile salts and bran in the diet were investigated in 1,2-dimethylhydrazine (DMH)-induced intestinal carcinogenesis in rats. Male Sprague-Dawley albino rats were divided into the following groups: group I, control; group II, 0.5% mixed bile salts; group III, 30 mg/kg DMH (10 weekly oral doses); group IV, bile salts and DMH; and group V, bile salts, 20% wheat bran and DMH. The bile salts and bran were added to a standard basal diet. The numbers of grossly observable colonic tumors per rat in groups III, IV and V were 10.8, 8.4 and 11.6, respectively. Microscopic classification of these tumors revealed 37/46 malignant tumors in group IV when compared to group III (28/68) and group V (43/77). Bile salts were cocarcinogenic but not cotumorigenic, i.e., bile salts caused no increase in the number of grossly observable tumors, but potentiated the formation of malignant tumors. Bile salts alone increased the labeling index of epithelial cell nuclei in the lower third of the colonic crypts, while in combination with DMH, they increased the number of cells/crypt. Addition of bile steroids significantly increased the incidence and number of malignant duodenal tumors. No significant differences in the fecal excretion of acidic steroids were observed between groups II, IV and V.

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Accession: 005699835

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PMID: 6252045


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