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Inhibition of coronavirus 229E replication by actinomycin D

Inhibition of coronavirus 229E replication by actinomycin D

Journal of Virology 29(1): 401-404

The yields of human coronavirus 229E grown in [human embryo lung] L132 cells were markedly inhibited by actinomycin D, the 50% inhibitory dose being 0.1 .mu.g/ml. Inhibition was maximal during the early phase of virus replication, did not appear to involve viral RNA synthesis per se, and was dependent on the input multiplicity of infection.

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Accession: 005702133

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PMID: 430598

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