Inhibition of gastric emptying in humans by secretion, the octapeptide of cholecystokinin, and intraduodenal fat

Valenzuela, J.E.; Defilippi, C.

Gastroenterology 81(5): 898-902


ISSN/ISBN: 0016-5085
PMID: 6269946
Accession: 005703226

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Intraduodenal fat is a potent inhibitor of gastric emptying. Neural and hormonal mechanisms are probably involved. Secretin and cholecystokinin are among the hormones known to be released by fat in the intestine. The effect of the octapeptide of cholecystokinin, secretin and intraduodenal oleate on the inhibition of gastric emptying of liquids in humans was investigated. On different days the gastric emptying of a 250-ml saline meal was studied in 6 healthy volunteers under the following conditions: during graded doses of the cholecystokinin-octapeptide alone; during graded doses of secretin; during graded doses of secretin with a background of the cholecystokinin-octapeptide, and during intraduodenal oleate perfusion. All the subjects were also studied for pancreatic enzyme secretion in response to the hormones and intraduodenal oleate. Low doses of secretin, that may be considered physiologic, delay gastric emptying of liquids in humans. The octapeptide of cholecystokinin at doses that may be considered physiologic for pancreatic secretion does not delay gastric emptying of liquids in humans. The secretin effect on gastric emptying is not potentiated by the cholecystokinin-octapeptide. Release of secretin may be one of the mechanisms that mediate the delayed gastric emptying in humans after intraduodenal oleate.