Inhibition of histamine-sensitive adenylate cyclase from the guinea pig gastric mucosa by nolinium bromide

Dousa, T.P.; Hui, Y.S.; Northrup, T.E.; Goldenberg, M.M.

Biochemical Pharmacology 28(2): 343-344


ISSN/ISBN: 0006-2952
PMID: 426848
Accession: 005703778

Download citation:  

Article/Abstract emailed within 1 workday
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Because of the potential importance of adenylate cyclase in the regulation of gastric HCl secretion, and because of considerable structural diversity between nolinium bromide (Nolinium Br) and classical H2-receptor antagonists the question of whether Nolinium Br may exert its HCl antisecretory effects through inhibition of histamine-stimulated adenylate cyclase was examined. The effects of Nolinium Br on basal adenylate cyclase activity and the activity stimulated by histamine, by prostaglandin [PG]E2 and by the non-hormonal stimulatory agents such as 5'-guanyl-iminodiphosphate [Gpp(NH)p] and NaF were studied. Nolinium Br acts as a rather specific inhibitor of histamine-stimulated adenylate cyclase from the gastric mucosa.