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Inhibition of plasmin by a small molecular weight inhibitor derived from human inter alpha trypsin inhibitor


Inhibition of plasmin by a small molecular weight inhibitor derived from human inter alpha trypsin inhibitor



Thrombosis Research 13(3): 563-568



ISSN/ISBN: 0049-3848

PMID: 84409

DOI: 10.1016/0049-3848(78)90143-3

Inter .alpha. trypsin inhibitor (I.alpha.I) was first identified as an inhibitor of trypsin and chymotrypsin. The antiplasminic activity of the 18,000 daltons inhibitory fragment derived from I.alpha.I was studied. The I.alpha.I derived fragment inhibited plasmin when synthetic substrates were used although the affinity for this enzyme is weaker than the one observed previously for trypsin. An esterolytic or an amidolytic assay alone might induce an erroneous appreciation of the inhibitory activity of a presumed inhibitor.

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Accession: 005706172

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