Section 6
Chapter 5,707

Inhibition of purified Escherichia coli leader peptidase by the leader (signal) peptide of bacteriophage M13 procoat

Wickner, W.; Moore, K.; Dibb, N.; Geissert, D.; Rice, M.

Journal of Bacteriology 169(8): 3821-3822


ISSN/ISBN: 0021-9193
PMID: 3301818
DOI: 10.1128/jb.169.8.3821-3822.1987
Accession: 005706687

The leader peptide of bacteriophage M13 procoat inhibited the cleavage of M13 procoat or pre-maltose-binding protein by purified Escherichia coli leader peptidase. This finding confirms inferences that the leader is the primary site of enzyme recognition and suggests a rationale for the rapid hydrolysis of leader peptides in vivo.

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