Section 6
Chapter 5,713

Injection of diethylstilbestrol on the 1st day of incubation affects morphology of sex glands and reproductive behavior of japanese quail coturnix coturnix japonica

Gildersleeve, R.P.; Tilson, H.A.; Mitchell, C.

Teratology 31(1): 101-110


ISSN/ISBN: 0040-3709
Accession: 005712138

Japanese quail [C. c. japonica] eggs were injected with DES [diethylstilbestrol] (0.9-1000 .mu.g) dissolved in 50-.mu.l of corn oil on day 1 of incubation. Higher doses of DES (250-1000 .mu.g) reduced hatchability to 37-33% compared to 61% for corn oil-injected controls. Lower doses of DES (0.9-125 .mu.g) had no effects on hatchability. In a 2nd study, eggs were injected with 0.9 or 1.9 .mu.g of DES and the survivors were assessed up to 12 wk posthatch. DES did not affect hatchability, but did increase mortality during the first 4 wk posthatch. Females were affected more than males. At 10 days of age, open-field activity of some birds was examined. The acquisition and reversal of a viaual discrimination task was studied at 6 wk of age. DES had no effect on these measurements. Females (10) from each group were chosen randomly to determine egg production over a single 28 day period beginning at 6 wk of age. Exposure to DES blocked egg production in these birds. The oviduct weights of 12 wk old females were decreased by 50%, but ovarian weight was not affected. Testicular weight was not affected. In a 3rd study reproductive behaviors and social-dominance behaviors of males were markedly attenuated in birds exposed to 0.48 or 1.9 .mu.g DES in ovo.

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