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Inorganic tin in the diet affects the femur in rats



Inorganic tin in the diet affects the femur in rats



Toxicology Letters 9(3): 207-210



The effects of dietary levels (10, 50, 100 and 250 ppm Sn) of stannous chloride on the femur were studied for 90 days on weanling male rats. The 100 and 250 ppm Sn significantly decreased serum Ca and serum Pi, Ca content in the femoral diaphysis and epiphysis, and acid phosphatase activity in the femoral epiphysis. Sn (50 ppm) produced significant reduction of serum Ca concentration and Ca content in the femoral epiphysis. These significant decreases were not observed with 10 ppm Sn. The maximal allowable concentration of inorganic Sn contained in a diet was < 50 ppm.

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Accession: 005713175

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PMID: 7314125

DOI: 10.1016/0378-4274(81)90150-8


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