Section 6
Chapter 5,731

Intergeneric co synthesis of penicillin by strains of penicillium chrysogenum penicillium notatum and aspergillus nidulans

Makins, J.F.; Allsop, A.; Holt, G.

Journal of General Microbiology 122(2): 339-344


ISSN/ISBN: 0022-1287
Accession: 005730051

A number of mutants impaired in penicillin production were previously isolated from P. chrysogenum and A. nidulans. During cofermentation of osmotically fragile mycelia derived from these strains, in the presence of inhibitors of cell wall regeneration, intergeneric cosynthesis was demonstrated between mutants which are probably impaired in different parts of the penicillin biosynthetic pathway.

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