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Intestinal absorption distribution and excretion of an orally administered polymeric anti oxidant in rats and mice



Intestinal absorption distribution and excretion of an orally administered polymeric anti oxidant in rats and mice



Food and Cosmetics Toxicology 16(4): 321-330



A new divinylbenzene-hydroquinone-phenols condensation polymer antioxidant (D00079), being developed for use in foods, was synthesized using [14C]divinylbenzene/ethylvinylbenzene. Peak MW was 4500 by gel-permeation chromatography relative to polystyrene standards. The metabolic fate of the radiolabeled antioxidant was studied in several test systems in rats and mice. In rats, intestinal absorption estimated from urinary and biliary excretion, expired CO2 and residual radioactivity in internal organs 96 h after oral administration was 0.2-0.6%, both in previously untreated animals and in animals fed the antioxidant at a dietary level of 5% for 13 wk. In bile-duct-ligated mice, intestinal absorption estimated from urinary excretion, expired CO2 and residual tissue radioactivity was 0.4%. Separate studies in rats with isolated dimer, trimer and tetramer-pentamer fractions of the polymer demonstrated that radioactivity absorbed after administration of the polymer could be accounted for almost entirely by absorption of 14C-labeled dimer species of MW 270. The minimal intestinal absorption of D00079 undoubtedly contributes to the lack of toxicity and to the absence of effects on hepatic microsomal oxidases seen in other studies in rats fed the antioxidant at dietary levels up to 5% for 13 wk.

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Accession: 005735322

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PMID: 711052


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