Intestinal absorption kinetics of various model drugs in relation to partition coefficients

Nook, T.; Doelker, E.; Buri, P.

International Journal of Pharmaceutics 43(1-2): 119-130


ISSN/ISBN: 0378-5173
DOI: 10.1016/0378-5173(88)90066-x
Accession: 005735332

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The kinetics of intestinal absorption of 9 drugs from aqueous solutions were studied in rats using an in situ perfusion technique. The results are discussed in the light of their partitioning behaviour, blood flow and the unstirred water layer. Correlations between absorption rate constants and partition coefficients were found to be either parabolic or hyperbolic and existing absorption models were applied to fit the data.