+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Intraperitoneal splenic implants do not alter clearance of pneumococcal bacteremia

Intraperitoneal splenic implants do not alter clearance of pneumococcal bacteremia

American Surgeon 51(5): 269-271

The effect of intraperitoneal splenic autotransplants was studied in Sprague-Dawley rats. Twenty animals underwent total splenectomy. Splenectomy was performed in another group of 20 rats, after which the spleen was diced into 15 pieces and replaced within the leaves of the small bowel mesentery. Twelve weeks later pneumococcal bacteremia was induced by intraperitoneal injection of 5 X 10(6) Streptococcus pneumoniae. Quantitative blood cultures were obtained from the tail vein 15, 30, 45, 60, 90, and 240 minutes after injection. Mean bacterial counts with time for animals bearing splenic autotransplants were not significantly different from completely asplenic rats. At autopsy, all animals receiving splenic implants were found to have viable splenic tissue among the leaves of the small bowel mesentery. This study shows that even allowing 12 weeks for maximal regeneration, splenic autotransplants fail to significantly alter the clearance of an established bacteremia.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 005743594

Download citation: RISBibTeXText

PMID: 3994168

Related references

Methods of splenic preservation and their effect on clearance of pneumococcal bacteremia. Annals of Surgery 202(5): 595-599, 1985

Depression of free water clearance during pneumococcal bacteremia. Annals of Surgery 177(1): 112-120, 1973

Complement mediated reticulo endothelial clearance in pneumococcal bacteremia. Federation Proceedings 39(3): ABSTRACT 4921, 1980

Blood clearance by anti-phosphocholine antibodies as a mechanism of protection in experimental pneumococcal bacteremia. Journal of Immunology 133(6): 3308-3312, 1984

The effect of site and technique of splenic tissue reimplantation on pneumococcal clearance from the blood. Journal of Pediatric Surgery 21(10): 877-880, 1986

Pneumococcal bacteremia in hawaii usa initial findings of a pneumococcal disease prevention project. Hawaii Medical Journal 48(12): 513-514, 517-518, 1989

Pneumococcal bacteremia in Hawaii: initial findings of a pneumococcal disease prevention project. Hawaii Medical Journal 48(12): 513-4, 517-8, 1989

Pneumococcal serotypes causing bacteremia and meningitis: relevance to composition of pneumococcal vaccine. Canadian Medical Association Journal 125(3): 263-267, 1981

Previous hospital care and pneumococcal bacteremia. Importance for pneumococcal immunization. Archives of Internal Medicine 143(5): 885-889, 1983

Is emergency room -based pneumococcal vaccination cost-effective for preventing pneumococcal bacteremia?. Clinical Infectious Diseases 31(1): 304, 2000

Acute terminal ileitis associated with pneumococcal bacteremia: case report and review of pneumococcal gastrointestinal diseases. Clinical Infectious Diseases 34(10): E50-E53, 2002

Epidemiology of pneumococcal bacteremia and meningitis during the first 5 years of life in Alaska Implications for conjugate pneumococcal vaccine use. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 39: 672, 1999

Pneumococcal bacteremia in febrile infants presenting to the emergency department before and after the introduction of the heptavalent pneumococcal vaccine. Annals of Emergency Medicine 49(6): 772-777, 2007

Prevention of pneumococcal bacteremia by immunization with type 6 pneumococcal capsular polysaccharide vaccine in splenectomized rats. Journal of Infectious Diseases 160(1): 66-75, 1989

Pneumococcal Bacteremia With Especial Reference To Bacteremic Pneumococcal Pneumonia. Annals of Internal Medicine 60: 759-776, 1964