Section 6
Chapter 5,748

Investigation of isozyme spectrum of lactate dehydrogenase and malate dehydrogenase in surgical patients with lung affections

Kharakter, Z.Z.; Mazhak, K.D.

Problemy Tuberkuleza 2: 36-39


ISSN/ISBN: 0032-9533
Accession: 005747307

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The isozyme spectra of lactate dehydrogenase (LDH) and malate dehydrogenase (MDH) were studied in 44 surgical patients with destructive tuberculosis and cancer of the lungs. A reliable decrease in the level of LDH1-2 as compared to that in 45 healthy persons, an increase in the level of LDH4-5 and the presence of a pathological mitochondrial fraction of MDH4 were observed in the patients before surgical operations. Within the 1st day after the operation there was a distinctive redistribution of the isozyme activity: an increase in the levels of LDH1 and a decrease in those of LDH3-5. In the patients with cancer of the lungs, the level of the cytoplasmic fraction of MDH1 markedly decreased and the level of the mitochondrial fractions of MDH3 and MDH4 increased. By the 5th day the relative activity of several isozymes of LDH and MDH reached the initial levels (those before the operations) and by the 10th day the majority of the indices gradually returned to normal.

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