Investigation of the lethal yellow Ay/Ay embryo using mouse chimaeras

Papaioannou, V.; Gardner, R.L.

Journal of Embryology and Experimental Morphology 52: 153-163


ISSN/ISBN: 0022-0752
PMID: 521747
Accession: 005748073

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In combination with intact, normal mouse blastocysts, surgically isolated inner cell masses from homozygous lethal yellow (Ay/Ay) embryos are capable of survival and normal development up to at least mid-gestation. In reciprocal experiments, normal inner cell masses did not prevent the early postimplantation loss of 25% of embryos from heterozygous matings. Ay apparently primarily affects the trophectoderm of the early embryo and death of an Ay/Ay embryo cannot be prevented by the presence of a normal inner cell mass. The homozygous lethal inner cell mass can be rescued in chimaeric combination with a normal blastocyst.