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Iso coumarins 5. synthesis of 2 8 di methyl 2 3 8 9 tetra hydro furo 2 3 f isocoumarin and 2 8 di methyl 1 2 8 9 tetra hydro furo 3 2 f isocoumarin



Iso coumarins 5. synthesis of 2 8 di methyl 2 3 8 9 tetra hydro furo 2 3 f isocoumarin and 2 8 di methyl 1 2 8 9 tetra hydro furo 3 2 f isocoumarin



Indian Journal of Chemistry Section B Organic Chemistry Including Medicinal Chemistry 20(9): 831-832



Allylation of 5-hydroxy-3-methyl-3,4-dihydroisocoumarin and 6-hydroxy-3-methyl-3,4-dihydroisocoumarin gave the corresponding allyloxy derivatives, which on Claisen rearrangement, followed by cyclization with HBr/AcOH furnish 2,8-dimethyl-2,3,8,9-tetrahydrofuro[2,3-f]isocoumarin and 2,8-dimethyl-1,2,8,9-tetrahydrofuro[3,2-f]isocoumarin, respectively. [Biological activity is discussed.].

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