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Isolated human cystic artery: responses to common agonist and antagonist drugs



Isolated human cystic artery: responses to common agonist and antagonist drugs



Pharmacology 22(2): 93-100



The extramural artery of the human gall bladder (cystic artery), a small artery (outside diameter 1.3 .+-. 0.03 mm) with a thick muscular wall and little elastin within the tunica media, has catecholamine fluorescence localized to the adventitia-medial border. Isolated helical strips of the artery are responsive to norepinephrine (NE), 5-hydroxytryptamine (5HT) and vasopressin (VP) at low concentrations, but at the maximal frequency of transmural electrical stimulation used (16 Hz), the response is only 10-20% of the NE maximum response. Phentolamine (2.7 .times. 10-6 M) antagonized responses to NE, 5HT and, to a lesser degree, electrical stimulation and these actions are similar to those reported in other mammalian tissue. In vitro use of reserpine (1.6 .times. 10-5 M) and guanethidine (4 .times. 10-5 M) also produced effects which were predictable from effects observed in other mammalian tissues; except reserpine diminished responsiveness to NE and 5HT and guanethidine enhanced responses to the early administered electrical stimulation.

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Accession: 005760209

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PMID: 7208597


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