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Labeling of nonpolyadenylic acid associated rna in the rabbit cerebral cortex 24 hours after a single electro convulsive shock



Labeling of nonpolyadenylic acid associated rna in the rabbit cerebral cortex 24 hours after a single electro convulsive shock



Neurochemical Research 7(10): 1223-1230



The labeling pattern of non-poly(A) associated (poly(A)-) RNA of rabbit cerebral cortex was studied 24 h after a single electroconvulsive shock (ECS). The animals were injected subarachnoidally with [3H]uridine and sacrificed 1 h later. The fractionation pattern of labeled nuclear poly(A)- RNA in the cerebral cortex of ECS treated animals was identical to that of the controls. Microsomal poly(A)- RNA from the treated animals showed an increased labeling of 18S rRNA. Also 28S RNA displayed a higher labeling but the effect was not statistically significant. There was a more efficient production of rRNA in the late post-ECS period which might be in relationship with an increased activity of brain protein synthesis machinery.

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