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Labeling pattern of rna in isolated perfused rat liver



Labeling pattern of rna in isolated perfused rat liver



Bollettino Societa Italiana Biologia Sperimentale 56(4): 295-301



The incorporation of 3H-orotic acid into nuclear and microsomal RNA from isolated perfused rat liver was studied. The specific radioactivity of nuclear RNA indicates that the efficiency for RNA synthesis in the perfused liver is a similar to that of the liver in vivo. The microsomal RNA specific radioactivity is well below that observed in vivo. This may indicate slower transport of the labeled RNA from the nucleus to the cytoplasm. Labeling pattern of total nuclear RNA, nuclear poly(A) containing RNA and microsomal RNA appear to be in line with these assumptions.

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Accession: 005787094

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