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Labetalol a crossover double blind controlled trial

Labetalol a crossover double blind controlled trial

European Journal of Clinical Pharmacology 14(5): 301-304

Twenty patients (12 female) with moderately severe essential hypertension [blood pressure during placebo treament 181 .+-. 6 (systolic), 107 .+-. 3 (diastolic)] completed a double-blind, cross-over dose-titrated comparison of labetalol and methyldopa. Both drugs reduced lying and standing arterial blood pressure to a similar extent, although only labetalol reduced heart rate. Compliance was high (> 95%) with both drugs and the incidence of subjective adverse effects was similar.

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Accession: 005787132

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PMID: 365543

DOI: 10.1007/bf00611897

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