+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Labetalol as a hypotensive agent in otological operations



Labetalol as a hypotensive agent in otological operations



Annales Chirurgiae et Gynaecologiae 68(2): 82-83



The usefulness of labetalol, a new combined alpha and beta adrenoceptor antagonist as a hypotensive agent in otological operations was studied in 18 otherwise healthy patients. After a single 1.0 mg/kg i.v. dose the maximum decrease in systolic (18%) and diastolic (8%) blood pressure occured between 5 to 15 minutes (mean 11 min), and the pretreatment blood pressure values were reached in 15 to 55 min (mean 26 min). Similarly, after a single 2.0 mg/kg i.v. dose the maximum blood pressure decrease (32%/20%) was observed in 5 to 40 minutes (mean 23.5 min) lasting 30 to 95 minutes (mean 60.1 min). Generally, a moderate decrease in blood pressure without a concomitant increase in heart rate or excessive hypotension was found.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 005787140

Download citation: RISBibTeXText

PMID: 41475


Related references

The use of labetalol as a moderate hypotensive agent in otological operations--plasma concentrations after intravenous administration. International Journal of Clinical Pharmacology, Therapy, and Toxicology 18(5): 191-194, 1980

Labetalol as a hypotensive agent for middle ear microsurgery. Acta Anaesthesiologica Scandinavica 31(3): 196-201, 1987

Labetalol used as a hypotensive agent in the presence of renal disease. Kidney International 11(4): 287-288, 1977

Acute haemodynamic effects of labetalol and its subsequent use of an oral hypotensive agent. British Journal of Clinical Pharmacology 3(4 Suppl 3): 789-793, 1976

A double-blind study with oral labetalol (Trandate)--a new hypotensive agent. Singapore Medical Journal 21(1): 474-478, 1980

Labetalol: a new hypotensive agent in surgery of the middle ear. Peroperative hemodynamic study. Annales Francaises D'anesthesie et de Reanimation 1(4): 387-392, 1982

Sodium nitro-prusside as a hypotensive agent during surgical operations. Praktische Anasthesie, Wiederbelebung und Intensivtherapie 9(1): 23-28, 1974

Ocular hypotensive action of labetalol. American Journal of Ophthalmology 88(3 PART 1): 427-431, 1979

Use of labetalol during hypotensive anaesthesia and in the management of phaeochromocytoma. British Journal of Clinical Pharmacology 8 Suppl 2: 229s-232s, 1979

Hypotensive and vascular effects of labetalol in the normotensive rat and dog. Japanese Heart Journal 19(5): 762-774, 1978

Poor hypotensive response and tachyphylaxis following intravenous labetalol. Current Medical Research and Opinion 5(5): 424-426, 1978

The hemodynamics and clinical effects of labetalol in hypotensive anesthesia. Zhonghua Yi Xue Za Zhi 45(1): 7-14, 1990

Rate of onset of hypotensive effect of oral labetalol. British Journal of Clinical Pharmacology 7(2): 165-168, 1979

Anesthesia in otological operations. Acta Oto-Rhino-Laryngologica Belgica 25(4): 686-691, 1971

The hypotensive effects and mechanism of SGB-483, a newly-synthesized hypotensive agent. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 79(5): 441-449, 1982