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Labetalol, beta blockers, and acute deterioration of chronic airway obstruction

Labetalol, beta blockers, and acute deterioration of chronic airway obstruction

Clinical and Experimental Hypertension. Part A, Theory and Practice 4(8): 1419-1428

The effects on lung function of labetalol (a combined .alpha.- and .beta.-adrenergic receptor blocker) and 3 .beta.-adrenergic receptor blockers (propranolol, atenolol, metoprolol) were assessed in patients with chronic airflow obstruction in a double-blind trial. With the dosages used, all drugs produced an equivalent fall of blood pressure. Propranolol was the only drug that significantly increased airways obstruction (FEV1 [1-s forced expiratory volume], specific airways resistance). Following salbutamol, labetalol was associated with a significantly greater improvement of airflow than propranolol or metoprolol. Based on these acute studies, the order of preference for .beta.-blocking drugs in management of hypertension in patients with [concurrent] obstructive airways disease is labetalol, atenolol or metoprolol, and then propranolol.

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Accession: 005787142

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PMID: 6126285

DOI: 10.3109/10641968209060799

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