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Labial salivary gland biopsy in sjogrens syndrome assessment as diagnostic criterion in 362 suspected cases

Labial salivary gland biopsy in sjogrens syndrome assessment as diagnostic criterion in 362 suspected cases

Arthritis & Rheumatism 27(2): 147-156

Xerostomia is an unsatisfactory diagnostic criterion for the salivary component of Sjogren's syndrome (SS). To determine the diagnostic usefulness of the presence of focal sialadenitis in labial salivary gland (LSG) biopsy specimens, 362 patients suspected of having SS prospectively underwent a unique LSG biopsy procedure. The pattern and severity of LSG inflammation were compared with measurements of parotid flow rate, and the presence or absence of symptomatic xerostomia, major salivary gland enlargement, keratoconjunctivitis sicca (KCS) and other connective tissue diseases (CTD). LSG biopsy focus scores of > 1 correlated more closely with the diagnoses of KCS alone and with KCS plus a CTD than did either reduced parotid flow rate or symptoms of xerostomia (P < 0.0005 and P < 0.05, respectively). Focal sialadenitis in an adequate LSG specimen is an objective criterion and a more disease-specific feature of SS than xerostomia or any other feature of salivary disease. The salivary component of SS should be redefined as the presence of LSG focal sialadenitis.

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Accession: 005787176

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PMID: 6696772

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