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Labile metabolites and phosphorylase a in rapidly frozen rat cerebral cortex



Labile metabolites and phosphorylase a in rapidly frozen rat cerebral cortex



Journal of Neurochemistry 30(2): 493-496



The influence of freezing speed was evaluated by analyses of phosphocreatine (PCr), ATP, ADP, AMP, cyclic AMP and phosphorylase a activity in cerebral cortex of lightly anesthetized rats. The freezing speed did not influence cerebral energy state. The somewhat lower ATP concentration observed in animals frozen through the dura was unassociated with increases in ADP or AMP (the size of the adenine nucleotide pool was lower). The results confirmed previous ones in showing that freezing of brain cortex through intact skull bone or exposed dura gives high values for PCr and ATP, and low values for ADP and AMP.

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Accession: 005787204

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PMID: 624954

DOI: 10.1111/j.1471-4159.1978.tb06555.x


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