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Labile testosterone conjugate in human urine further evidence



Labile testosterone conjugate in human urine further evidence



Clinica Chimica Acta 93(2): 227-234



The origin of unconjugated testosterone released in human urine on storage and by dilute sulfuric acid treatment was studied. Various extraction procedures of urine were employed along with a new methodology involving anion exchange followed by acid hydrolysis and radioimmunoassay of the released unconjugated testosterone. Human urine contains a very labile conjugate of testosterone and 5.alpha.-dehydrotestosterone with polar solubility properties and a negative charge.

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Accession: 005787217

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PMID: 445843

DOI: 10.1016/0009-8981(79)90093-7


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