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Lability of renal papillary tissue composition in the rat



Lability of renal papillary tissue composition in the rat



Journal of Physiology 274: 323-328



1. The acute effects of (a) a minor operative procedure using ether as the anaesthetic, and (b) the administration of 0.9% saline as a single I.V. injection in the conscious rat, on renal tissue composition were studied in hydropenic and normally hydrated rats. 2. The operative procedure and anaesthesia induced a rapid and transient decrease in papillary osmolality in both hydropenic and normally hydrated animals, the important contributing factor being a significant decrease in urea content. 3. Administration of a small volume of saline caused a rapid decrease in urea content, and an increase in water content. 4. It is concluded that papillary composition is extremely labile, large changes being produced by relatively minor experimental procedures.

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Accession: 005787235

Download citation: RISBibTeXText

PMID: 624997

DOI: 10.1113/jphysiol.1978.sp012150


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