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Laboratory and clinical studies of spiro germanium a novel hetero cyclic anti cancer drug



Laboratory and clinical studies of spiro germanium a novel hetero cyclic anti cancer drug



Drugs under Experimental & Clinical Research 8(4): 379-386



Spirogermanium is a newly-developed anticancer drug of novel heterocyclic structure. Although its mode of action has not yet been fully elucidated, it appears that spirogermanium inhibits DNA, RNA and protein synthesis and is not a phase or cell cycle specific drug. It revealed activity in vivo against i.p. implanted [rat] Walker 256 sarcoma, 137762 mammary adenocarcinoma and 11095 prostatic carcinoma in rats, but no antitumor activity in vivo was found in the murine tumors used in the past by the NCI screen ([mouse] L 1210 and [mouse] P 388 leukemia, [mouse] B 16 melanoma, [mouse] Lewis lung carcinoma). Spirogermanium is remarkable for its lack of bone marrow toxicity; moderate, predictable and reversible CNS toxicity is dose-limiting. Activity in malignant lymphoma, ovarian cancer and large bowel cancer was reported in initial clinical studies conducted in the USA and Sweden. The drug is currently under clinical investigation in other malignancies. The dose of 50-80 mg/m2, given by 60' infusion 3 times a wk, is currently used and well-tolerated in Phase II clinical studies. Of interest are preliminary results reported in this paper on spirogermanium in vitro activity against the human leukemia line K 562 and resistant strains of Plasmodium falciparum at concentrations possibly achievable in vivo, suggesting clinical exploration of both original findings.

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